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Firstly, 2C-B Powder Dark Market. Psychedelics have been traditionally classified by either their chemical structure or primary mechanism of action into two classes: serotonergic hallucinogens (indolamines, e.g., psilocybin and LSD) and phenylethylamines [e.g., mescaline and 2,5-dimethoxy-4-iodoamphetamine (DOI)] (Vollenweider, 2001; Aarde and Taffe, 2017). Recently. 2C-B Powder Dark Web. However, new psychoactive substances (NPSs) developed from both substitutions and well-known structures have emerged. 2C-B Powder For Sale

Such novel psychedelics include the 2C-series and its structural analogs, including N-Benzylphenethylamines (NBOMes) (Tracy et al., 2017). 2C-series, also called 2C-drugs/compounds, are a related group of substances with presumably psychedelic and psychostimulant properties. All of them are phenylethylamine derivatives structurally close to mescaline with methoxy substitutions. At the 2 and 5 positions derived from the two carbon molecules between the benzene ring and the amino group. 2,5-dimethoxy-4-bromophenethylamine (2C-B, Nexus) is one of the oldest and best known 2C-type drugs.

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Secondly, Based on the abrupt introduction of 2-CB onto the drug market, 2C-B and any of its salts or isomers were added to Schedule II of the 1971 Convention on Psychotropic Substances by the UN Commission on Narcotic Drugs in 2001 (United Nations Office on Drugs and Crime [UNODC], 1971; de Boer and Bosman, 2004).

The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) and the United Nations Office on Drugs and Crime (UNDOC) classified it as an NPS (European Monitoring Centre for Drugs and Drug Addiction [EMCDDA], 2011; United Nations Office on Drugs and Crime [UNODC], 2013). In some Latin American countries as Colombia, also 2C-B is consider an NPS due to its recent presence in the market (Colombia National Study of Psychoactive Substance Consumption, 2013).

From a pharmacological point of view, preclinical studies have demonstrated that 2C-drugs inhibit the norepinephrine (NE). And serotonin transporters (NET and SERT, respectively) with very low potency in comparison to amphetamines (Glennon et al., 1984; Vollenweider and Kometer, 2010). Regarding 2C-B, as other hallucinogenic phenethylamines, is a partial agonist of 5HT2A, 5HT2B, and 5HT2C receptors (Rickli et al., 2015; Luethi et al., 2017). Other studies however have reported that may act as a 5HT2A full antagonist (Villalobos et al., 2004). 2C-B Powder Dark Market

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It elicits weak response (5–10%) in both phospholipase A2–arachidonic acid (PLA2–AA) release and phospholipase C-inositol phosphate (PLC-IP) accumulation on 5HT2A receptors (Kurrasch-Orbaugh et al., 2003; Moya et al., 2007). The metabolism of 2C-B has been studied in experimental animals and in vivo models (Kanamori et al., 2002, 2005; Carmo et al., 2004; Theobald et al., 2007). It is generally assume that 2C-B is metabolize mainly by the monoamine oxidase enzymes, MAO-A and MAO-B, and, to a lesser degree, by the CYP450 system (Carmo et al., 2005; Pichini et al., 2008; Kanamori et al., 2013, 2017). 2C-B Powder For Sale

Urine analysis from a 2C-B abuser have identified and quantified unchanged 2C-B and nine different metabolites suggesting that 2C-B is metabolized to an alcoholic metabolite [4-bromo-2,5-dimethoxyphenylethylalcohol (2C-B-ALC)], and a carboxylated metabolite [4-bromo-2,5-dimethoxyphenylacetic acid (2C-B-CBA) (Kanamori et al., 2013, 2017). Currently, there are not data available describing active metabolites that could contribute to overall effects, therefore, 2C-B seems the active one while the rest are inactive or nearly. 2C-B Powder Dark Web

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Data concerning prevalence and patterns of use of novel psychedelics are limited. In 2013, almost half of the Global Drug Survey [GDS] (2013) respondents (2,282, 46.4%) reported lifetime use of at least one NPS. Of these, 21.7% described psychedelic phenethylamine lifetime use, with 18.4% corresponding to the 2C series. The most common being 2C-B (n = 291, 12.97%) (Palamar et al., 2016). In Australia, a survey among regular ecstasy users showed that 44% had used an NPS in the last 6 months. Mainly 4-iodo-2,5-dimethoxyphenethylamine (2C-I, 14%) and 2C-B (8%) (Burns et al., 2014).

The latest data from the GDS, which included a non-representative sample of 115,000 subjects. Suggest an increase in the consumption of drugs with a psychedelic effect profile (including LSD analogs), representing over 50% of the total NPSs. Estimated life-time and past year use of 2C-B was 5.1 and 2.7%, respectively (Global Drug Survey [GDS], 2017). 2C-B Powder Dark Web

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Regarding trends in the United Kingdom, psychedelic use over the last 4 years was stable at around 7% with the exception of 2016 in which it rose to 9.8% (7.7-6.3-9.8-7.1%). Globally, 6.3% of the previous 12 month 2C-drug users suffered difficult/negative experiences while under the influence of psychedelics. In Central and South America, 2C-B has become a very popular nightlife NPS (Colombia National Study of Psychoactive Substance Consumption, 2013). 2C-B is usually taken orally in powder or tablet form, in doses of 10–30 mg. Tablets typically contain 5–10 mg of the substance. An oral low dose is consider to be 5–10 mg, a medium dose 10–25 mg, and a high dose 25–40 mg (Caudevilla-Gálligo et al., 2012; Nugteren-van Lonkhuyzen et al., 2015; Papoutsis et al., 2015). 2C-B Powder For Sale

With the exception of emerging 2C-B research performed in the 1950s–1970s by Shulgin, who reported a maximum oral dose of 100 mg without apparent harm (Shulgin and Carter, 1975; Shulgin and Shulgin, 1990), limited clinical research has been conducted in humans.

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In short, Current evidence about 2C-B acute effects in humans comes from intoxications collected at Poison Information Centers (Burns et al., 2014; Srisuma et al., 2015), self-reports from research chemical recreational users (questionnaires and surveys) (Caudevilla-Gálligo et al., 2012; González et al., 2013), and intoxication cases (Ambrose et al., 2010; Huang and Bai, 2011;

In conclusion, Hondebrink et al., 2015; Liakoni et al., 2015; Caicedo et al., 2016), the clinical presentation including typical hallucinations (tactile, visual, and auditory) and neuropsychiatric symptoms (anxiety, agitation, and confusion). While a number of fatalities have been link to other substances in the 2C-drug group none have been attribute to 2C-B alone. 2C-B Powder Dark Market

To sum up, We have recently published a manuscript about the acute pharmacological effects of 2C-B focused on emotions. Results showed a specific profile suggesting 2C-B classification as an entactogen drug with psychedelic properties (González et al., 2015). The purpose of the present study is to assess the acute pharmacological effects and oral fluid pharmacokinetics of 2C-B in humans. 2C-B Powder Dark Web