Wockhardt Codeine (liquid) For Sale
$350.00 – $1,250.00
Wockhardt Promethazine Codeine Each 5 ML contains: Promethazine hydrochloride 6.25 mg; codeine phosphate 10 mg. Alcohol 7%. Indication: Cough Suppressant Dosage Form: Syrup Validity: 2 years Strength 200 mg 16 oz, 32 oz.
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Firstly, Wockhardt Codeine For Sale. Wockhardt syrup kaufen also contains: Purified Water, Sodium Citrate Dihydrate, Edetate Disodium, Sodium Benzoate, Sodium Propionate, Saccharin Sodium, Ascorbic Acid, Liquid Sugar, Glycerin, Citric Acid Anhydrous, Dehydrated Alcohol; Methylparaben, F, D & C Red #40, F,D, & C Blue #1, D & C Red #33, Artificial Raspberry Flavor. All concentrations are in percent by weight unless ingredient is a gas. Codeine For Sale Online. Gas concentrations are in percent by volume. Components not listed are either non-hazardous or are below reportable limits. Promethazine With Codeine Oral
Secondly, It is a made of combination of prescription-strength cough medicine, soft drinks, and hard, fruit-flavored candy. The prescription cough syrups used to make lean drink present the most danger because they often contain codeine, an opioid drug. Another active ingredient in some prescription cough syrups is promethazine, an antihistamine with potentially sedating effects that, in combination with opioids, could markedly impair motor functioning.
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Furthermore, Codeine is one of the naturally occurring phenanthrene alkaloids of opium derived from the opium poppy; it is classified pharmacologically as a narcotic analgesic. Codeine phosphate may be chemically designate as 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate (1:1)(salt) hemihydrate.
The phosphate salt of codeine occurs as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and slightly soluble in alcohol. It has a molecular weight of 406.37, a molecular formula of C18H21NO3•H3PO4•½H2O, and the following structural formula:
Ultra-Rapid Metabolism of Codeine and Other Risk Factors for Life-Threatening Respiratory Depression in Children
In addition, Life-threatening respiratory depression and death have occurred in children who received codeine. Most of the reported cases occurred following tonsillectomy and/or adenoidectomy, and many of the children had evidence of being an ultra-rapid metabolizer of codeine due to a CYP2D6 polymorphism. Promethazine HCl and Codeine Phosphate Oral Solution is contraindicate in children younger than 12 years of age and in children younger than 18 years of age following tonsillectomy and/or adenoidectomy (see CONTRAINDICATIONS). Avoid the use of Promethazine HCl and Codeine Phosphate Oral Solution in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine. (See WARNINGS – ULTRA-RAPID METABOLISM OF CODEINE AND RESPIRATORY DEPRESSION). Codeine For Sale Online
Postmarketing cases of respiratory depression, including fatalities have been report with use of promethazine in pediatric patients. Children may be particularly sensitive to the additive respiratory depressant effects when promethazine is combine with other respiratory depressants, including codeine. (See WARNINGS – PROMETHAZINE AND RESPIRATORY DEPRESSION IN CHILDREN). Promethazine With Codeine Oral
Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants
Nevertheless, Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death (see WARNINGS, PRECAUTIONS – DRUG INTERACTIONS). Avoid use of opioid cough medications in patients taking benzodiazepines, other CNS depressants, or alcohol
Narcotic analgesics, including codeine, exert their primary effects on the central nervous system and gastrointestinal tract. The analgesic effects of codeine are due to its central action; however, the precise sites of action have not been determine, and the mechanisms involve appear to be quite complex. Codeine resembles morphine both structurally and pharmacologically, but its actions at the doses of codeine used therapeutically are milder, with less sedation, respiratory depression, and gastrointestinal, urinary, and pupillary effects. This produces an increase in biliary tract pressure, but less than morphine or meperidine. Codeine is less constipating than morphine.
Moreover, Codeine has good antitussive activity, although less than that of morphine at equal doses. It is use in preference to morphine, because side effects are infrequent at the usual antitussive dose of codeine.
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Codeine in oral therapeutic dosage does not usually exert major effects on the cardiovascular system.
Narcotic analgesics may cause nausea and vomiting by stimulating the chemoreceptor trigger zone (CTZ); however, they also depress the vomiting center, so that subsequent doses are unlikely to produce vomiting. Nausea is minimal after usual oral doses of codeine.
Narcotic analgesics cause histamine release, which appears to be responsible for wheals or urticaria sometimes seen at the site of injection on parenteral administration. Histamine release may also produce dilation of cutaneous blood vessels, with resultant flushing of the face and neck, pruritus, and sweating.
Meanwhile, Codeine and its salts are well absorb following both oral and parenteral administration. It is about 2/3 as effective orally as parenterally. Codeine is metabolize primarily in the liver by enzymes of the endoplasmic reticulum, where it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid. The drug is excrete primarily in the urine, largely as inactive metabolites and small amounts of free and conjugate morphine. Negligible amounts of codeine and its metabolites are found in the feces. Codeine For Sale Online
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To sum up, the cough-depressing action, in animal studies, was observed to occur 15 minutes after oral administration of codeine, peak action at 45 to 60 minutes after ingestion. The duration of action, which is dose-dependent, usually did not exceed 3 hours.
Promethazine is a phenothiazine derivative which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. It is thought that this configuration is responsible for its lack (1/10 that of chlorpromazine) of dopamine antagonist properties.
In conclusion, Promethazine is an H1 receptor blocking agent. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects.
Promethazine is well absorbed from the gastrointestinal tract. Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although they may persist as long as 12 hours. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Promethazine With Codeine Oral. Wockhardt Codeine For Sale
Promethazine HCl and Codeine Phosphate Oral Solution is contraindicated in all children younger than 12 years of age. (See WARNINGS – ULTRA- RAPID METABOLISM OF CODEINE AND RESPIRATORY DEPRESSION).
To short, Promethazine HCl and Codeine Phosphate Oral Solution is contraindicated for postoperative management. In children younger than 18 years who have undergone tonsillectomy and/or adenoidectomy. (See WARNINGS – ULTRA- RAPID METABOLISM OF CODEINE AND RESPIRATORY DEPRESSION).
Codeine is contraindicated in patients with a known hypersensitivity to the drug. Codeine For Sale Online
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